San Francisco Giants at New York Yankees odds, picks and predictions

The San Francisco Giants and New York Yankees swing into the 2023 season with a Thursday matinee at Yankee Stadium. First pitch is slated for 1:05 p.m. ET. Let's analyze Tipico Sportsbook's lines around the Giants vs. Yankeesodds and make our expert MLB picks and predictions for the best bets.

Season series: First meeting since 2019 when the Yankees swept 3 games in San Francisco.

San Francisco went 81-81 and placed 3rd in the NL West last season. The Giants were 14-7 with a plus-40 in run differential in April, but struggled after that. The Giants were somewhat undone by a 22-27 record in 1-run games.

New York was a bit record-unlucky in 2022, only parlaying a plus-1.48 in average run differential into a 99-63 record. The Yankees logged a pedestrian 42-39 mark on the road, but they tied the Los Angeles Dodgers for the best home record in MLB at 57-24.