Santa Clara vs. Wyoming odds, line, bets: 2022 college basketball picks, Nov. 30 predictions from proven model

Wyoming Cowboys (3-3) are on a losing streak. They play Santa Clara Broncos (5-2) on Wednesday at 4 p.m. ET. Santa Teresa is on two-game winning streak and is favored by 5.5 points. The over/under is set at 136. SportsLine's computer model simulates every Division I college basketball game 10,000 times and has returned profitable returns for its players.

Santa Clara vs. Wyoming is a college basketball game on November 30th. The game is worth 136 points. Santa Clara is favored by 5.5 points, while Wyoming's favorite is +220.

Santa Clara vs. Wyoming is a college basketball game. The game is expected to be played on November 30th.

Wyoming is without its best player, Hunter Maldonado, who suffered a head injury on Monday. Santa Clara beat Iona on Sunday. Brandin Podziemski scored 27 points and grabbed nine rebounds. The Broncos have covered the spread in 15 of their last 20 games. Wyoming has failed to cover the spreads in each of its last seven games dating back to last season.

Wyoming has won five of its last six games against West Coast Conference opponents. Wyoming has plenty of players capable of playing well without Maldonado and Agbonkpolo. Santa Clara has struggled against teams from the Mountain West, covering the spread three times in their last 11 tries.

The model simulating Santa Clara vs. Wyoming is leaning Over. It also generated a point-spread pick that is hitting in over 60% of simulations.