SMU vs. Tulane prediction, odds, line: 2022 Week 12 college football picks, best bets from proven model

The SMU Mustangs are trying to stay hot on Thursday when they play the Tulane Green Wave at Yulman Stadium in New Orleans. The Mustang's are still alive to make the conference championship game but need a victory on the road. Tulana is in a three-way tie for first in the AAC standings and can clinch a spot in December's title game by beating SMu and Cincinnati.

Tulane and SMU are college football teams that play each other on Saturday. The Green Wave are favored by 3.5 points. SMu is favored to win by more than 150 points, but SportsLine's model has picked the Green Waves.

Tulane and SMU are playing each other in the Week 12 college football game. The Green Wave are the third-ranked passing team in passing yards allowed per game (175.5). SMu is the second-best receiving team (116.7).

Tulane's defense has done a great job this season at limiting big plays. The Green Wave rank fifth in the country in both 10-plus yard plays allowed (92) and 30- plus yard play allowed. Michael Pratt is one of the best quarterbacks in AAC. He faces a defense that allows 248.4 passing yards per game.

Tanner Mordecai is one of the most prolific quarterbacks in the country. He is a semifinalist for the Davey O'Brien Award. SMU has dominated the series against Tulane recently.

SportsLine's model is leaning Over on the point total and has generated an against-the-spread pick that hits more than 50% of the time.