Thursday Night Football odds, spread, line: Chargers vs. Chiefs prediction, NFL picks from expert who's 17-5

The Kansas City Chiefs host the Los Angeles Chargers on Thursday Night Football at 8:15 p.m. ET. Both teams are 1-0 to begin the season and led by elite quarterbacks. Caesars Sportsbook lists Kansas Chiefs as a four-point home favorite. The over/under is 54.5 in the latest Chargers vs. Chiefs odds. SportsLine expert R.J. White is a top NFL expert and has gone 445-378-24 on his ATS picks from 2017-21. He's also gone 17-5-1 on NFL picks involving the Chargers.

The Chiefs are 11-10 against the spread in the last 21 games. The Chiefs money line is -210. Los Angeles is 9-9 against-the-spread in last 18 games and is +175 against Chiefs.

Chargers vs. Chiefs is Thursday Night Football. The Chiefs are 11-10 against the spread in the last 21 games.

Herbert has the most touchdown passes and second-most passing yards through the first 33 starts in NFL history. Herbert has a dual-threat with more than 500 rushing yards in 33 career starts. He has also experienced success on the road in Kansas City with 583 passingyards, 7 touchdown and no interceptions at Arrowhead Stadium.

Kansas City has one of the most prolific passing combinations in the NFL. Patrick Mahomes threw for more yards and touchdowns than any other player in Week 1. The Chiefs finished in top four of NFL in total offense and scoring offense last season. Travis Kelce caught eight passes for 121 yards in opener. Kelter has a six-year streak of at least 1,000 receiving yards.

The Chiefs and Chargers are playing on Thursday Night Football. White is leaning Under on the point total. He also has a critical X-factor that makes one side of the spread a must-back.