Chargers at Chiefs predictions: Point spread, total, player props, pick, trends for 'Thursday Night Football'

The opening game of the week will be aired on Amazon's Prime Video. Justin Herbert and Patrick Mahomes are going to play against each other at Arrowhead Stadium. The game is one of one the best quarterback matchups of this season.

The Chiefs are a -4 favorite on the betting line. The line opened in May. After the opening weekend, the Chiefs' edge increased to -3.5.

Kansas City's Patrick Mahomes threw for five touchdowns in the Chiefs' win over the Cardinals in Week 1. Keenan Allen and J.C. Jackson are injured and Herbert will be without them. Arrowhead Stadium is one of the better home-field advantages in NFL.

Kansas City is 6-1 ATS in its last seven games as a home favorite.

The total is 54.5. The over/under is 50. Both teams have good offensive firepower.

The Chargers are going for the over 54 points. The Chiefs are fresh off dropping 44 points in Arizona. In Kansas City's last nine games, the Over is 8-1. For the Chargers, it's 6-0 in their last seven games.

The Chiefs are 5-1 over the last six Thursday night games.

Patrick Mahomes has thrown 46 passing touchdowns with just three interceptions in his career. The Chiefs quarterback has historically played well out of the gate. Free agent corner Jackson will make his debut for the Chargers.

Justin Herbert has played well at Arrowhead in his two starts. Herbert's touchdown total is -224.5. The Chargers have plenty of weapons in the passing game, including Mike Williams and Austin Ekeler.

Austin Ekeler is going to play a lot with Allen out. Travis Kelce's longest reception is over 22.5 yards. The Chiefs defense allowed Darren Waller to average 19.8 yards per catch in the opener. Chiefs are playing the Chargers on Thursday Night Football.