US Open 2022: John Isner vs Holger Rune preview, head-to-head, prediction, odds and pick

John Isner and Holger Rune will play each other at the US Open 2022 on September 1, 2022.

John Isner and Holger Rune are playing in the US Open 2022.

John Isner and Holger Rune will meet in the US Open 2022.

John Isner and Holger Rune are playing at the US Open 2022 in New York.

John Isner and Holger Rune are going to play each other at the US Open 2022.

John Isner and Holger Rune will play each other in the second round of the US Open on Thursday. Iser hasn't won a title this year but reached the final of ATP 250 Houston Open. Rune won his first ATP title at the Munich Open and reached a career-high ranking of 28 in August.

John Isner and Holger Rune have a head-to-head record. Thursday's match will be their first meeting.

John Isner vs. Holger Rune is a US Open match-up for 2022.

John Isner is the favorite heading into the US Open. Rune is in the midst of a breakout season. Iser has arguably the best serve in tennis. He served 19 aces and won 88% of the points on his first serve against Rune.