USMNT vs. Japan prediction, odds, spread, line: International friendly picks, best bets for Friday, Sept. 23

The U.S. Men's National Team is preparing for the 2022 World Cup. On Friday, they play a friendly against Japan in Düsseldorf, Germany. The team's next match is against Saudi Arabia on Tuesday. They start World cup play on November 21 against Wales. Kickoff is at 8:26 a.m. ET. Japan is listed as +150 favorites on the 90-minute money line. USA are +165 underdogs. A draw is +210, and the over/under for total goals is 2.5.

Jesus Ferreira has the potential to score goals for the USMNT. Sergiño Dest will be back on the roster against Japan. The AC Milan fullback hasn't played for USmNT since January.

Matt Turner has played only one match for Arsenal. Ethan Horvath has started 10 games for Luton Town. Sean Johnson is tied for the MLS lead in clean sheets. Takumi Minamino has 17 goals in 42 career appearances with Japan.

Eimer has analyzed USA vs. Japan and is picking Over 2.5 goals. He also has two other confident picks for Japan vs USA. SportsLine is sharing these USMNT vs Japan picks at Sportsline.