Buffalo Bills vs LA Rams Picks, Best Bets & Predictions For 2022 NFL Kickoff Game

The 2022 NFL betting season is starting with the Los Angeles Rams vs. Buffalo Bills. The Rams are defending their Super Bowl championship. Bills led the league in scoring last year and are considered by many to be the top team in 2022.

The Rams are the defending Super Bowl champions. The Rams have covered in every game under coach Sean McVay. Matthew Stafford is feeling well and should be able to play. The best bet is to take the points with the host Rams.

The total on betting apps jumped from 52 points to 53 for the NFL Kickoff Game, then fell back to 52. The top play is a Kickoffs Game Under for Rams vs Bills picks. Buffalo ranked No. 1 in fewest points allowed in 2021, the Rams were middle-of-the-pack but allowed just 18.8 ppg in the playoffs.

The road team has won the NFL Kickoff Game just three times since 2003. Most of the home teams in the past were the favorites.

Buffalo Bills are the favorites in the primetime game against LA Rams.

Neither side on the moneyline is appealing for your Rams vs. Bills picks.

Josh Allen and Matthew Stafford are both elite quarterbacks. They have two passing touchdowns each in 21 games. The Bills and Rams ranked 1 and 2 in fewest pass TDs allowed in 2021.

Matthew Stafford has a target increase with the addition of Allen Robinson II. The Bills allowed the fewest pass yards of any team in 2021. Stafford finished over 268.5 passyards 10 times.

Darrell Henderson averaged 2.4 receptions per game for the Rams last year. Cam Akers is back in the mix and both are expected to be used nearly equal. Henderson's pass targets are likely to go down with Aker's return. Buffalo allowed fewer receptions to RBs than the LA Rams did last season.