Chargers vs. Colts Prediction, Odds, and Picks for Week 16

The Los Angeles Chargers and Indianapolis Colts are playing for their playoff lives in Week 16. The current NFL betting odds and key storylines are listed below.

The L.A. Chargers are on a two-game winning streak and are now in the AFC's fifth place. The Colts are coming off a historic defeat against Minnesota. Jonathan Taylor is injured and will miss the rest of the season for the Colts. The Chargers and Colts will play each other on Sunday. They are both currently in 9-6 on the year. It's possible that the Chargers could advance to the postseason. If so, they could play against the team that is currently fifth in AFC. Indianapolis is 4-9 and lost to Minnesota last week. Jeff Saturday's team is struggling to find a permanent head coach.