Cleveland Guardians at San Francisco Giants odds, picks and predictions
The Cleveland Guardians (68-77) and the San Francisco Giants (74-70) play the 2nd contest of a 3-game series Tuesday night at Oracle Park. First pitch is scheduled for 9:45 p.m. ET (MLB Network). Let’s analyze BetMGM Sportsbook’s lines around the Guardians vs. Giants odds and make our expert MLB picks and predictions for the best bets.
Season series: Giants lead 1-0
The Guardians fell 5-4 in 10 innings despite jumping out to a 4-3 lead in the top of the frame. Closer RHP Emmanuel Clase was unable to hold the lead, coughing up 2 runs and 2 hits with a balk against the 2 batters he faced, and he was unable to return any batters.
The Giants have racked up 4 straight victories, bouncing back after a 6-game skid from Sept. 1-6. San Francisco has re-discovered its offense during the win streak, averaging 7.3 runs per game while cashing the Over in all 4 contests.
Guardians at Giants projected starters
RHP Cal Quantrill vs. LHP Sean Manaea
Quantrill (2-6, 5.70 ERA) makes his 16th start. He has a 1.46 WHIP, 3.1 BB/9 and 5.2 K/9 through 79 IP.
- Last start: No-decision, 6 IP, 0 ER, 3 H, 2 BB, 6 K in 3-2 road loss vs. the Los Angeles Angels Thursday
- 2023 road splits: 1-2, 5.40 ERA (43 1/3 IP, 26 ER), 5 HR, .277 opponent batting average (OBA) in 8 starts
Manaea (5-5, 5.00 ERA) makes his 7th start and 34th overall appearance. He has a 1.32 WHIP, 3.8 BB/9 and 10.6 K/9 through 93 2/3 IP.
- Last start: No-decision, 3 IP, 2 ER, 4 H, 0 BB, 1 K in 8-2 road loss vs. the Chicago Cubs Wednesday
- 2023 home splits: 2-4, SV, 3.74 ERA (45 2/3 IP, 19 ER), 7 HR, .212 OBA in 4 starts and 12 relief appearances
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Guardians at Giants odds
BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 6:25 a.m. ET.
Guardians at Giants picks and predictions
Prediction
Giants 6, Guardians 4
The GIANTS (-145) are a strong play as moderate favorites against the very giving Quantrill. The right-handed Guardians hurler has a dismal 5.40 ERA on the road, serving up 5 HR in just 43 1/3 IP with teams hitting .277 against him away from home.
Manaea hasn’t been that much better, but the Giants offense is on fire lately. That’s not a good thing for Q, who cannot put up donuts on the scoreboard lately.
The GIANTS -1.5 (+145) are a solid play at plus-money. While San Francisco didn’t cover Monday, and it barely even won, the Giants are 6-5 on the run line in the past 11 games as a favorite.
The Guardians are just 2-7 in the past 9 games overall and are 2-3 on the run line in their last 5 as underdogs.
The OVER 8.5 (-105) is the play lately, as the San Francisco offense has been on fire this past week. The Giants have plated 29 runs in the past 4 games, cashing the Over in each of those outings. The Over also has a 6-5 edge in the past 11 interleague games for San Francisco and is 3-1 in the past 4 interleague contests for Cleveland.
