Giants vs. Panthers odds, line, spread, prediction: 2022 NFL picks, Week 2 best bets from model on 139-98 run

The Carolina Panthers lost to the Cleveland Browns in the first game of the season. The New York Giants defeated the Tennessee Titans 21-20 in their home opener. They are a 2-point favorite against the Panthers. SportsLine's computer model simulates every NFL game 10,000 times and has returned a 139-98 record on top-rated NFL picks since 2017.

SportsLine's computer simulation simulated Giants vs. Panthers 10,000 times and revealed its NFL expert picks and predictions. Giants are 17-8-1 ATS versus teams with losing records.

Giants vs. Panthers is a game with a 43.5-point over/under. The money line is New York -130. Carolina is 4-1 ATS in their last five games in September. Giants are 17-8-2 AATS versus teams with losing records.

Giants beat Tennessee 21-20 last week. New York is feeling good after picking up the win. Running back Saquon Barkley had 18 carries for 164 yards and a score in the game. He also had six receptions for 30 yards.

Carolina's offense has plenty of playmakers, including Christian McCaffrey, D.J. Moore and Robbie Anderson. The Temple product Moore led the team last week with five receptions for 102 yards, and a 75-yard touchdown grab.

SportsLine's computer model has a 139-98 record on its best bets from Week 2. It's leaning Under the total and has strong against the spread pick.