NFL Week 15 Odds: Super Bowl Hopes for Bills Tested at Home vs. Cowboys

There is a trio of Saturday games highlighting the slate for the first time this season as we take an initial peek at the NFL Week 15 odds and betting lines from our best NFL betting sites.

The NFL Week 15 slate gets underway with a Thursday Night Football matchup between a pair of 5-7 AFC West foes when the Los Angeles Chargers visit the Las Vegas Raiders. 

Saturday features a contest between the Pittsburgh Steelers (7-5) and Indianapolis Colts (7-5) — two teams vying for the final wild-card spots in the AFC.

The game most likely to shake up the Super Bowl odds is a Sunday afternoon affair between the Dallas Cowboys and Buffalo Bills. Buffalo was among the preseason favorites to win the AFC but finds itself outside the postseason picture.

Eyes will also be on the Philadelphia Eagles vs. Seattle Seahawks on Monday Night Football, with Philly vying for the No. 1 seed in the NFC.

Here’s a closer look at all of the NFL Week 15 odds from our best sports betting sites.  

NFL Week 15 odds and lines

There's an advantage to betting the early NFL odds while trying to beat the closing line. The closer you wait until kickoff to make your NFL picks, the more difficult it becomes to identify edges and secure the best number on most sides or totals.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach is the first step to long-term success.

Best NFL Week 15 spreads

A whopping eight home underdogs pepper the Week 15 slate opening lines that you can get by using our Caesars promo code: SBRBONUS1000. 

Only three games on the week feature spreads of greater than seven points, and all three pass the 10-point threshold. Two of those games are a half point from moving to a full 14-point spread, as the Dolphins and 49ers are giving up 13.5 points.

Four games have a margin at or less than a field goal, with the tightest game of the week being the Bills giving up a single point at home to the Cowboys.

Best NFL Week 15 moneylines

The Chiefs, Saints, Dolphins, 49ers, and Rams are the largest favorites looking ahead to Week 15. Some of these lines will surely experience notable movement in the coming days with all the quarterback uncertainty surrounding Week 14 as backups receive more playing time and injuries develop.

Best NFL Week 15 Over/Unders

Due to quarterback play and injuries, totals nearing 50 have been few and far between over the back half of the season, and we're seeing that again in Week 15 with a high projected total of 49 in the Cowboys-Bills affair. Just two games are in the key range of 43-44, while six games have totals lower than 40.

NFL betting odds pages

Here are ourbest NFL betting sites:

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