NFL Week 10 Odds & Betting Lines

Here’s our breakdown of the opening NFL Week 10 odds and betting lines from our best NFL betting sites.

There’s no way to sugarcoat the lackluster primetime NFL games in Week 10, and there is also a lack of must-watch bouts during the first two Sunday time slots. 

With the Kansas City Chiefs, Philadelphia Eagles, and Miami Dolphins all on their bye weeks, a number of the shortest favorites in the Super Bowl odds and NFL MVP odds aren’t in action.

Still, the opening NFL odds would suggest there will be a lot of close games. And, at this time of the season, there are always postseason implications to up the ante.

 I’m particularly interested in the San Francisco 49ers-Jacksonville Jaguars game. Both teams are coming off a bye, and they’re both trending in opposite directions. San Fran has dropped three straight, while Jacksonville’s five-game winning streak will be the longest in the NFL regardless of what happens in Week 9.

Alright, let's take a closer look at all of the NFL opening odds for Week 10 via our best sports betting sites.

NFL Week 10 odd and lines

There's an advantage to betting NFL odds early and trying to beat the closing line in NFL markets. The closer to Sunday you wait to make your NFL picks, the more difficult it becomes to identify edges and secure the best price on a side or total.

That's why it's important to start monitoring the NFL opening odds each week as soon as possible. A proactive approach will aid your long-term success.

Best NFL Week 10 spreads

There are only two divisional matchups in Week 10, with the Baltimore Ravens hosting the Cleveland Browns, and the New York Giants visiting the Dallas Cowboys. Interestingly, it’s the second consecutive NFC East matchup for Dallas, and the Cowboys were also the only team to play within their division in Week 9.

Additionally, there are just three games with a spread above a touchdown, and there are also only four home underdogs in the opening betting odds.

Best NFL Week 10 moneylines

The Cincinnati Bengals, Cowboys and Buffalo Bills are the largest favorites on the docket, while the Jaguars, Minnesota Vikings and Las Vegas Raiders are the only home teams trading at plus-money.

With so many small spreads and moneylines that are close to even-money, I'm anticipating a lot of minor adjustments to the numbers following the Week 9 games.

Best NFL Week 10 Over/Unders

The only two totals above the key range of 43-44 are in the games between the Detroit Lions and Los Angeles Chargers, and the Denver Broncos and Buffalo. There are four games with a total below 40.

NFL betting odds pages

Here are ourbest NFL betting sites:

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