Patriots vs. Vikings odds, spread, line: 2022 Thanksgiving Day NFL picks, predictions from expert who's 52-28

Minnesota Vikings host New England Patriots at U.S. Bank Stadium on Thanksgiving. The Vikings are 8-2 and lead the NFC North. NewEngland is 6-4 and tied for third place in the AFC East. Minnesota is a 2.5-point favorite. SportsLine's resident Vikings expert, R.J. White, is an expert in NFL picks. He's gone 445-378-24 on his ATS picks from 2017-21.

SportsLine's expert picks Minnesota Vikings vs. New England Patriots during the 2022 Thanksgiving NFL schedule. The Vikings are favored by 2.5 points.

Vikings vs. Patriots money line is Minnesota -145, New England +120. Vikings vs Patriots over/under is 42.5 points.

Justin Jefferson is one of the best receivers in the NFL. Minnesota has been winning the turnover battle all season. The Vikings' 18 takeaways are tied for third in NFL, behind only the Eagles and Ravens.

Matthew Judon leads the NFL in sacks with 13. New England's defense is one of the best in the league. The Patriots give up 16.9 points per game and 302.8 yards per match.

White has analyzed this matchup and is leaning Under. He has discovered a crucial x-factor that makes one side of the spread a must-back.