Vikings vs. Colts prediction, odds, line, spread: 2022 NFL picks, Week 15 best bets by model on 157-113 run

The Indianapolis Colts (4-8-1) will visit the Minnesota Vikings (10-3) on Saturday at 1 p.m. ET. The Colts have won the last six games against Minnesota, while the Vikings haven't won since 1997. SportsLine's computer simulation model simulates every NFL game 10,000 times and has returned a profit of more than $7,700 for $100 players on top-rated NFL picks since its inception.

Colts vs. Vikings is a game on Saturday. The Vikings are 8-2 against the spread in their last 10 games in Week 15. Colts are 5-1 ATS in last six Saturday games.

Colts vs. Vikings money line is Minnesota -195, Indianapolis +162. Colts are 5-1 ATS in their last six Saturday games.

Dalvin Cook is a dynamic and electric ball-carrier. T.J. Hockenson provides Minnesota with a big target over the middle. Adam Thielen is an outstanding possession receiver with outstanding body control. The two-time Pro Bowler has recorded 60-plus yards in two of the last three games.

The Colts are ranked third in pass defense. Zaire Franklin is the engine of this group. Bobby Okereke is second on the team in total tackles (108) and tied for 11th in solo stops (70).

SportsLine's model is leaning Over on the point total. The model also says one side hits well over 50% of the time.