2022 College Football Week 2 Odds, Picks & Betting Predictions

Georgia, Ohio State and Florida won their home games in the opening weekend. Alabama is a -20.5 favorite to beat Texas. Kentucky is going to play Florida. Baylor is playing No. 25 BYU in Utah. The game is nightcap of the night game.

2022 College Football Week 2 Odds & Point Spreads. Don't forget to shop around at sportsbooks and on available betting apps for the best price and college football week 2 spreads.

2022 College Football Week 2 Odds, Picks & Betting Predictions are accurate as of publication (Sept. 9).

Alabama and Texas are playing each other on September 10 at 12 p.m. ET. Alabama is a significant favorite (-17.5) but the line has since moved three points in Alabama's favor.

Tennessee and Pittsburgh are playing each other on September 10th at 3:30 p.m. ET. Pittsburgh won the first game against West Virginia 38-31. Tennessee won 59-10 over Ball State.

Washington State and Wisconsin are playing each other on September 10 at 3:30 p.m. ET. Wisconsin is two-score favorites. Washington State is coming off a one-point win over Idaho.

Iowa State is a 3.5-point favorite against Iowa. Iowa State won 42-10 over Southeast Missouri last week. The Hawkeyes didn't score a touchdown in their 7-3 victory over South Dakota State.

Kentucky and Florida are playing each other on September 10 at 7 p.m. ET. Florida just beat Utah in a thriller. Kentucky won the first game 37-13 over Miami (Ohio). Florida is a -5.5 to -4. 5 favorite.

Arizona State is a big road underdog against Oklahoma State. The Cowboys won the opener against Central Michigan. Arizona State won last weekend 40-3 over Northern Arizona.

Stanford and USC are playing each other in the second week of college football. The Trojans are favored by more than a touchdown. Stanford has fallen on hard times in recent years and David Shaw's tenure could be in jeopardy.

Baylor and BYU are playing each other on September 10 at 10:15 p.m. ET. Baylor's offense looked efficient in their 69-10 win over Albany, but BYU's defense is a different challenge.