2022 MLB odds, picks, bets for Wednesday, Sept. 28 from proven model: This four-way parlay pays more than 24-1

Tyler Glasnow returns from Tommy John surgery to make his first start since June 14, 2021. He will start for Tampa Bay against the Cleveland Guardians at Progressive Field in Cleveland. The game is one of 15 on the MLB schedule for Wednesday. Aaron Judge takes another shot at tying the American League single-season home run record. Dodgers and Padres play in San Diego. SportsLine's proven computer model simulates every MLB game 10,000 times and has returned almost $900 for $100 players. It has four confident MLB best bets for the penultimate week of the regular season.

The model is backing St. Louis to beat Milwaukee. The Cardinals have won three of the last four meetings against the Brewers. Milwaukee has lost four of its last five home games. St Louis is 9-1 in games started by Jose Quintana since he was acquired at the trade deadline.

The model has selected a four-way parlay with bets that pay more than 24-1. SportsLine's model also has three other best bets for Wednesday.