2023 MLB picks, odds, best bets for Wednesday, May 17 from top model: This four-way parlay pays more than 8-1

The AL East will remain the center of attention as part of the 15-game Wednesday MLB schedule. The Toronto Blue Jays and New York Yankees will continue their tense feud, while the division-leading Rays will try to pile more misery on the New York Mets. The four-game Blue Jays vs. Yankees series started Monday with a 7-4 New York victory marred by sign-stealing accusations. New York won again Tuesday, 6-3, behind a homer by Aaron Judge, his third in the two games. The Rays improved their MLB-best record to 32-11 with an 8-5 victory Tuesday in New York, humiliating Mets starter Justin Verlander in his first start at Citi Field. 

First pitch in Blue Jays vs. Yankees is set for 7:07 p.m. ET. Caesars Sportsbook lists Toronto as the -105 favorite (risk $105 to win $100) in its latest MLB odds. New York is priced at +143, and the over/under for total runs scored is 8. With 14 other games on the Wednesday MLB schedule, there are many possibilities for wagers. Before you make any MLB picks for Wednesday, be sure to .

The SportsLine Projection Model simulates every MLB game 10,000 times. It went 331-285 on top-rated MLB money-line picks (+357) over the past two seasons. It has opened the 2023 MLB season on a 20-15 roll on all-top rated MLB picks. Anybody who has followed it has seen profitable returns. 

Now, the model has locked in four confident MLB best bets for Wednesday. They all involve games starting after 6:35 p.m. ET, so there's plenty of time to get these MLB picks in. If you successfully parlay the picks, you'd be looking at a payout of more than 8-1. You can only see the model's MLB picks for Wednesday at SportsLine. 

Top MLB picks today

One key part of the model's MLB parlay is Over 8.5 runs (-115) in Rays vs. Mets (7:10 p.m. ET). The Rays have gone over in five straight, and the Over is 4-1 in the past five meetings between these teams. The Rays are the highest-scoring team in MLB, averaging 6.3 runs per game. The Mets are averaging 4.4, and while they are struggling, they still have a potent lineup. New York is led by Pete Alonso, who shares the MLB lead for home runs after hitting his 14th in Tuesday's loss. The Rays hammered Verlander, chasing him after five innings where he allowed six runs.

Isaac Paredes had two home runs and five RBI in the victory. He became the 10th Rays player to reach five homers, an MLB record through a team's first 50 games – the Rays have played 43. Tampa Bay will have another "opener" on the mound Wednesday, and it's expected to be Josh Fleming. The left-hander's last two appearances came against the Yankees, and he allowed seven runs on 10 hits, including two home runs. Expected Mets starter Kodai Senga comes off a 5-0 loss to the Reds last Thursday, surrendering eight hits and all five runs. See who else to back here.

How to make MLB parlays for Wednesday

The model has locked in three other best bets for Wednesday, including a confident play on an underdog that is winning in well over 60% of its simulations. You can see the model's MLB best bets and parlay only at SportsLine.