49ers vs. Rams Predictions, Picks & Odds Week 2: Will Purdy's Streak Continue at Rams’ House?

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16 September 2023

49ers vs. Rams Predictions, Picks & Odds Week 2: Will Purdy's Streak Continue at Rams’ House?

The San Francisco 49ers and head coach Kyle Shanahan have had the upper hand on Sean McVay and the Los Angeles Rams in recent seasons but can the SoCal club turn things around on Sunday as we look at our top 49ers vs. Rams predictions based on the best NFL odds from our best sports betting apps?

The San Francisco 49ers have won eight straight regular-season games against the Los Angeles Rams, and even during rough years, such as 2020, the Niners managed to top their division rivals.

Expectations were low for the 2023 Rams, but they surprised with an impressive 30-13 road win over the Seattle Seahawks in Week 1. Quarterback Matt Stafford threw for 334 yards, and rookie wide receiver Puka Nacua made history by becoming the fifth player in the last 60 years to amass 10 or more receptions in his NFL debut.

To complement your NFL best bets for Week 2, NFL upset picks and NFL player props here is our best 49ers vs. Rams prediction (odds via our best NFL betting sites; pick confidence based on a1-to-5-star scale).

49ers vs. Rams prediction

Over 44.5 points (-115 via FanDuel)⭐⭐⭐⭐

As good as the Rams’ win was in Seattle lastweek, the Seahawks’ defense is not as strong as San Francisco’s. The Niners’ Dled the league last season in points allowed and was tied for second in takeaways.Despite new defensive coordinator Steve Wilkes, they don’t appear to havechanged much in 2023.

Second-year defensive end Drake Jackson rung up threesacks in Week 1, while the defense held the Pittsburgh Steelers to just 3.9 yards per play with a 33% third-down conversion rate and kept Pittsburgh QB Kenny Pickett to a 68.4 QB rating. That was even without defensive end Nick Bosa beingfully reintegrated with his team.

The 49ers rushed for 150-plus yards in sixstraight regular-season games, tied for the team's second-longest streak. But, as McVay and the rest of the NFL know, Shanahan’s offenseis a juggernaut. They punish opponents on the ground and through the air. Niners QB BrockPurdy threw two touchdown passes to wide receiver Brandon Aiyuk in San Francisco's 30-7victory at Pittsburgh last Sunday. Purdy is the first QB in NFLhistory to win each of his first six career regular-season starts and throw atleast two touchdown passes in each.

Wide receivers TutuAtwell and Nacua each had 119 receiving yards in the Rams’ win in Seattle.If there's a weak spot for the 49ers' defense, it's against slot receivers. CooperKupp, unavailable for this game, averaged 110.25 receiving yards pergame in his last four meetings with San Francisco, so McVay knows how tomove the ball against them.

It'sa divisional matchup that averaged 42.5 points per game over the last four regularseason meetings. With Shanahan’s offense firing on all cylinders, takethe Over.

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49ers vs. Rams best odds

The total opened at 43.5 and droppedas low as 42.5 Monday. Since late Monday afternoon it's hovered around44.5 and 45. Both teams had 30 points last Sunday, and although the Ramswill find it tougher to score against San Francisco’s defense, McVay should havesomething schemed up.

The line had considerable movement Friday,with three of our best sports betting apps moving it up from 44.5 to 45.5. FanDuel is theonly book to drop its line, although the odds increased to -115. Take fewer yards to ensure the win. This is a total very much in your grasp.

49ers vs. Rams odds

The Rams are huge underdogs at home in adivisional matchup. They’re +7 ATS with some of our best sports betting sites. FanDuel has thebest odds for the spread at -110.

There’s little value in betting the 49ers onthe moneyline at -320. The odds dropped significantly overnight Thursday,with the public favoring San Francisco. If you think L.A. can cause anupset, the moneyline odds are +270, up from +240 on Thursday.

Purdy is -110 to throw over 1.5 touchdownpasses against the Rams. Stafford is +134 for the same play.