Monday Night Football odds, spread, line: 49ers vs. Rams predictions, NFL picks from Niners expert who is 17-6

The Los Angeles Rams and San Francisco 49ers are playing on Monday Night Football. The Rams are 2-1 overall and 1-0 on the road this season. San Fran is 2 points favorites. SportsLine expert Tom Fornelli has covered in NFL games for CBS and is 17-6 on his picks involving the 49er.

Rams are 11-13 against the spread in their last 24 games. 49ers are 13-10 against a spread against teams in last 23 games, including 13.10 in the last two weeks.

49ers vs. Rams is Monday Night Football. The money line is 49ers -130 and Rams -110. Over/under is 42.5 points.

The Rams have strengths on both sides of the ball. Matthew Stafford and Cooper Kupp have a good connection. The Rams forced seven turnovers in three games this season. Aaron Donald is the team's anchor with five straight seasons featuring double-digit sacks. San Francisco is No. 24 or worse among NFL teams in scoring offense, total offense and passing offense.

The 49ers are off to a good start on the defensive side. Los Angeles is No. 25 in total yards and No 28 in turnovers. The 49er's defense is second in the league in terms of yards per drive, first downs allowed, opponent yards, and passing yards allowed.

Fornelli is a 17-6 NFL expert who is sharing his picks for Monday Night Football. Forneri is leaning Under on the point total but he has discovered an X-factor that has him jumping all over one side of the spread.