Alabama vs. Vanderbilt odds, line: 2022 college football picks, Week 4 predictions from proven computer model

The Alabama Crimson Tide are undefeated and they face the Vanderbilt Commodores on Saturday at 7:30 p.m. ET. Alabama is favored by 40.5 points. The over-under is set at 59. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of more than $3,300 for $100 players on its top-rated college basketball picks.

Alabama is the favorite against Vanderbilt. The game is scheduled for this Saturday. Alabama is a 40-5 favorite.

Alabama vs. Vanderbilt is a college football game. The line is Alabama -40.5.

Alabama has dominated Vanderbilt over the past 40 years. Crimson Tide covered the 49.5-point spread in a 63-7 blowout against Louisiana-Monroe last week. Vanderbilt freshman quarterback AJ Swann will be making his second career start in front of one of the loudest crowds in the country.

Vanderbilt is one of five FBS teams with two road wins this season. Vanderbilt converted all 17 of its red zone trips into touchdowns or field goals. Alabama has games against No. 10 Arkansas, No., 23 Texas A&M and No, 11 Tennessee.

The model has simulated Alabama vs. Vanderbilt 10,000 times and the results are in. It's leaning Over on the total and it's generated a point-spread pick that's hitting in well over 50% of simulations.