Auburn vs. Missouri prediction, odds, line: 2022 Week 4 college football picks, bets by model on 51-43 run

Auburn and Missouri are playing each other in the 2022 college football season. Missouri finished in a fourth-place tie with South Carolina last year and is coming off a 34-17 win over Abilene Christian last Saturday. Auburn finished tied for sixth with LSU in SEC West and finished 6-7 overall in 2021. The Tigers lost 41-12 to Penn State on Saturday, but are 3-0 in this series.

Auburn and Missouri are playing each other in the Week 4 college football game. Auburn is 6-1 against the spread in their last seven games. Missouri is 4-0 in its last four games against a team with a winning record.

Missouri and Auburn are playing in the Week 4 college football game. Auburn is 6-1 against the spread in their last seven games following a double-digit loss at home.

Auburn has scored eight touchdowns rushing through the first three games. Jarquez Hunter is third in the SEC and 20th nationally in scoring at 10.0 points per game. Tank Bigsby has 38 carries for 237 yards (6.2 average) and three touchdowns.

Auburn is not a lock to cover the Missouri vs. Auburn spread. Missouri's quarterback Brady Cook has played well in his team's last two wins. Dominic Lovett is the team’s top receiver.

SportsLine's model is leaning Over the total and projecting 57 combined points for Auburn and Missouri. It has also generated an against the spread pick that cashes in well over 50% of simulations.