Clemson vs. Wake Forest odds, prediction, line: 2022 Week 4 college football picks by model on 51-43 run

No. 5 Clemson Tigers take on the No. 21 Wake Forest Demon Deacons in an ACC Atlantic Division game on Saturday at noon ET. The Tigers have won nine straight games. Wake is looking to build off last year's success. Clemson leads the all-time series 69-17-1. SportsLine's advanced computer simulation model simulates every FBS college football game 10,000 times. It has generated a stunning profit of more than $3,300 for $100 players on its top-rated collegeFootball picks against the spread.

Clemson is favored by 7 points against Wake Forest. The Tigers are 4-0 against the spread in their last four conference games. Wakeford is 4.1-1 ATS in its last five games in September.

Clemson is 4-0 against the spread in their last four conference games. Wake Forest is also 4 of 5 ATS in its last five games in September.

Clemson is averaging more than 41 points per game. DJ Uiagalelei is the team's leading passer with 662 yards and 5 touchdowns. Will Shipley is second on the Tigers in rushing with 249 yards on 32 carries and 6 touchdowns, and third on receptions with 28 yards. Shiply has multiple rushing touchdowns in seven of his 13 career games.

Wake Forest has a potent offense led by junior quarterback Sam Hartman. Sophomore wide receiver Taylor Morin has 13 receptions for 139 yards (10.7 average) and two touchdowns. Last season, Morins had career highs with 43 receptions, 621 yards and five touchdowns, ranking third on the team in each category.

SportsLine's model is leaning Over on the point total. The model also says one side of the spread hits in well over 50% of simulations.