Celtics vs. Spurs prediction, odds, line: 2022 NBA picks, Jan. 5 best bets from model on 50-27 run

The San Antonio Spurs visit Boston Celtics on Wednesday at 7:30 p.m. ET. The Celtics are listed as 7.5-point home favorites. San Antonio has won seven of the last 10 games against Boston. SportsLine's computer model simulates every NBA game 10,000 times and has returned well over $10,00 in profit on its top-rated NBA picks over the past three-plus seasons.

Celtics vs. Spurs is a 2018 NBA game. The Celtics are 8-9-1 against the spread in home games. San Antonio Spurs are 3-3 against a spread against Celtics in the last six games with no rest.

Spurs vs. Celtics money line is Celtics -330, Spurs +260. Spurs are 3-3 against the spread in the last 6 games with no rest. Boston Celtics are 8-9-1 against spread at home.

San Antonio's offense is off to a strong start in 2021-22. The Spurs are scoring 1.1 points per possession and shooting 46 percent. San Antonio is also making headway on the offensive glass, securing more than 27 percent of available rebounds. On defense, the Spurs rank above-average in steals and blocks, with top-six rankings in free throw prevention and fast break points allowed. Boston is in the bottom 10 of the NBA in field goal percentage, 3-point percentage and assists.

Celtics are holding opponents to 1.07 points per possession and holding them to 34.3 percent shooting from 3-point range. San Antonio is No. 29 in the NBA in 3 3s per game and in bottom three in free throw attempts and free-throw percentage. Boston is in top five in field goal percentage (44.1 percent) and two-pointer percentage 50.6 percent.

SportsLine's model is leaning under on the total and predicts the teams to combine for 218 points. One side of the spread hits in over 50 percent of simulations.