Giants vs. Cardinals Predictions, Picks & Odds Week 2: Big Blue Defense Restores Pride in the Desert

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16 September 2023

Giants vs. Cardinals Predictions, Picks & Odds Week 2: Big Blue Defense Restores Pride in the Desert

The Arizona Cardinals and rookie head coach Jonathan Gannon host the New York Giants in Week 2, as we share our top Giants vs. Cardinals predictions based on the best NFL odds across our best sports betting apps.

Opinions on these two teams may have shifted this week with the Dallas Cowboys blowing out the New York Giants 40-0 at MetLife Stadium, while the Arizona Cardinals displayed a spirited road performance against the Washington Commanders in a 20-16 loss.

However, don't be misled by the Cardinals' performance. Their offense struggled with Joshua Dobbs starting at quarterback. Despite completing 21 of 30 passes (70%), Dobbs managed just 132 passing yards, and Arizona failed to score an offensive touchdown.

Scoring may be scarce in this matchup, but trust New York head coach Brian Daboll to outsmart his first-year counterpart, Arizona head coach Jonathan Gannon.

Here is our best Giants vs. Cardinals prediction to complement your NFL best bets for Week 2, NFL upset picks and NFL player props (odds via our best NFL betting sites; pick confidence based on a1-to-5-star scale).

Giants vs. Cardinals prediction

Giants -4 (-110 via DraftKings, bet365,BetMGM,Caesars) ⭐⭐⭐⭐

The Cardinals were 1-8 (.111) in home gameslast season, an NFL second-worst, ahead of the Houston Texans (0-7-1). Their eight home losses were a franchise single-season high,breaking the mark set in 2018 (1-7). The team has gottenworse. They traded away talent, quarterback Kyler Murray is still injured and Dobbs is their placeholder starter. The Washington Commanders gifted Arizona with turnoverslast weekend.

Although Giants QB Daniel Jones did have two fumbles andtwo interceptions of his own against the Cowboys last week, they were upagainst an NFL top-two defense. Dallas generated pressure on 23 of theGiants’ 37 dropbacks.

Last season, Jones had a career-best 67.2% completion rate with a personal-low five regular-season interceptions.He'll want to return to that level of consistency in Glendale Sunday. Jones had a team-high 13 rushing attempts (for 43 yards) in Week 1.

But the Giants’ run game doesn’t have torely on him. Running back Saquon Barkley had 607 rushing yards in road games last season, a league fourth most, behind Derrick Henry (905), Josh Jacobs (868) and NickChubb (727). What makes this even more impressive is he played only seven road matchups last year; each of the other three played nine.

Expect the Giants' D to feast on a weakCardinals' O-line, and for New York to control the ball on the ground. Joneswon’t have to throw much, as the Giants maintain possession and cover thespread.

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Giants vs. Cardinals best odds

bet365,BetMGM,DraftKings,Caesars -110

This line opened -4 on the NFL Week 2 odds but got as highas -5.5 on Tuesday. If this got to -6 or -6.5 I’d have strongly considered theCardinals as home underdogs. However, -4 is a good number, and, as bad as theGiants looked Sunday night, they have superior coaching and a strongerroster to cover on the road.

DraftKings raised its odds from -112 to-110, in line with our best sports betting sites. Caesars had the line at -4.5at the start of Friday but pushed it down to -4. That blowout win by the Cowboys worked in our favor.

Giants vs. Cardinals odds

With these two offenses in action, there aren’tmany points expected in this contest. Our best sportsbooks have the total at 39.5. Consider the Under, which you can get as high as -104 via FanDuel. FanDuelalso has the Giants priced at -220 straight up, with the same book offering the bestmoneyline odds for the Cardinals at +184.

The line for total rushing yards for Jones is 35.5, while he’s priced at -110 for the Over at bet365. Other books havethis line set at 37.5 yards, so shop around.