Houston Astros vs. Arizona Diamondbacks MLB picks, predictions, odds

The Arizona Diamondbacks host the Houston Astros at Chase Field in Phoenix on Wednesday.

The game is scheduled to begin at 12:40 p.m. MST and can be seen on Bally Sports Arizona and AT&T SportsNet Southwest.

Who will win the MLB game?

The Astros are a 1.5-run favorite in the game, according to Tipico Sportsbook.

Houston is -180 on the money line and Arizona is +145.

The over/under is set at 8.5 runs.

Covers.com: Take the Astros to cover vs. Diamondbacks

JD Yonke writes: "We’re backing the Astros in this spot. They’re the better team, have the better lineup, and will have the better pitcher on the mound. The money line looks like it possesses some value across most books, but we’ll be taking the better odds by laying -1.5 on the run line."

Fansided: Take the under in Diamondbacks vs. Astros game

Iain MacMillan writes: "It's a small sample size, but the Diamondbacks bats have been the worst in the Majors through the first week of action. They're dead last in both batting average at .130 and OPS at .518. Things won't get any easier for them, as they now face the Astros top starter who pitched 6.2 scoreless innings in his first start of the year. To be fair, I'm also a believer in the Diamondbacks starter today, Merrill Kelly, who I predict will take a big step forward this year. He showed promise in the shortened 2020 season, throwing for an ERA of 2.59, and I think he'll return closer to that form this year. I think the total is way too high in this one, I'll gladly take the under."

Tony's picks: Astros 5, Diamondbacks 2

It writes: "Framber Valdez played well in his season debut, winning 3-1 over the Los Angeles Angels.  Through 6.2 innings, Valdez had zero runs on 2 hits and 6 strikeouts.  Merill Kelly also had a good start, with zero runs on 4 hits in 4 innings.  The UNDER has cashed in for Houston in 8 of their last 11 games.  Taking the game on the road is the Houston Astros with a final score prediction and play UNDER 5-2."

Stat Salt: Go with the Astros against the Diamondbacks

Devin Erickson writes: "In 2021 these teams finished at opposite ends of the spectrum with Houston winning 95 games and Arizona tying for the worst record in baseball with 110 losses. While it's early, 2022 appears to be headed in a similar direction for both clubs. While Merrill Kelly looked sharp in his season debut, Framber Valdez looked even better. Valdez will have no issues slicing through one of the weaker lineups in baseball. Look for Houston to build on last night's hard-fought win. Houston is 4-1 in their last five while Arizona is 1-4 in their last five. Expect these trends to continue."

Number Fire: Astros have a 63.3% win probability

The site has the Astros as the favorite for Wednesday's MLB game at Chase Field in Phoenix.

Pick Dawgz: Go with the under in Astros vs. Diamondbacks game

Shane Mickle writes: "Getting the start for the Astros will be Famber Valdez who was good in his first start against the Angels giving up two hits and zero runs. On the mound for the Diamondbacks will be Merrill Kelly and in his first start against the Padres he went four innings and gave up four hits and zero runs. The Astros are 1-4 in their last five interleague road games. The Diamondbacks are 38-100 in their last 138 games. The under is 5-2 in the Astros last seven road games. The Astros are 5-1 in the last six meetings. The Astros are 2-4 in the last six meetings in Arizona.  Both of these pitchers have been good to start the season and especially the Diamondbacks are a team that are going to have issues scoring in this game. Look for a 3-2 type of game and this game is going to go under the total. I am also throwing a few dollars on the Diamondbacks to pull the upset at a nice price."

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