How to watch Louisville vs. Duke football: Odds, Jeff Brohm team info

Louisville's aggressive defense has been key in the No. 18 Cardinals' success this season.

The unit has made timely stops and is tied with Arizona (39th nationally) in points allowed (20.6). U of L ranks fourth in red zone defense. The Cardinals have been particularly strong against the run, holding opposing offenses to 97.1 yards per game, 14th fewest in the country.

Being overly aggressive sometimes has resulted in big plays for Louisville's opponents. The Cardinals will look to balance aggression and efficiency against No. 21 Duke at 3:30 p.m. Saturday at L&N Stadium.

"We've just got to make sure that we continue to know the right combination of being aggressive and yet safe," Louisville coach Jeff Brohm said. "You look at the Notre Dame game, we were aggressive on defense, but we were efficient. ... In football, you gotta win the small details. The turnover battle, third-down conversions and giving up big plays is some of the things we need to get better at."

Here's what you need to know ahead of Louisville's ACC game against Duke:

Louisville vs. Duke football pregame notes

• Louisville leads the all-time series with Duke, 3-0. During the last meeting in 2021, former Cardinals quarterback Malik Cunningham had a career performance with 303 passing yards, 224 rushing yards and seven touchdowns in the 62-22 victory.
• The Cardinals are 54-59-1 all time in games that follow a bye week. Brohm has a career record of 6-4 in games after an open date.
• Louisville announced it will play James Madison on Sept. 6, 2025. The Cardinals were originally scheduled to play Indiana, but the Hoosiers canceled the final two games of a three-game series. It'll be only the second time that the Cardinals and Dukes have met. U of L defeated JMU, 34-10, last season.
• After North Carolina's upset loss to Virginia, the Cardinals' latest bowl projection has them headed to the CapitalOne Orange Bowl on Dec. 30 in Miami. Louisville's last Orange Bowl appearance was in 2007, when the squad defeated Wake Forest, 24-13, ending the season with a program-record 12 wins.

Louisville vs. Duke pregame football reading

Louisville vs. Duke odds

Louisville remains a 4-point home favorite over Duke, according to DraftKings.

How to watch Louisville vs. Duke football

Who: Louisville (6-1, 3-1 ACC) vs. Duke (5-2, 2-1)

When: 3:30 p.m. Saturday, Oct. 28

Where: L&N Stadium, Louisville

TV: Sean McDonough (play-by-play) and Greg McElroy (analyst) will have the call on ESPN.

Radio: Paul Rogers (play-by-play) and Craig Swabek (analyst) will call the game on Louisville Radio Network (93.9 FM and 970 AM).      

Streaming: Qualified subscribers can stream the game at espn.com/watch.

Reach Louisville football, women's basketball and baseball beat writer Alexis Cubit at [email protected] and follow her on X at @Alexis_Cubit.