Indianapolis Colts vs Las Vegas Raiders Odds, Predictions and Best Bets for Week 10

The Indianapolis Colts have lost three games in a row and fired coach Frank Reich on Monday. The Colts were beaten 26-3 by the New England Patriots in Foxborough. Jeff Saturday, most recently an ESPN analyst, takes over after having never coached at the college or professional level.

The Raiders are 4.5-point favorites and -225 on the moneyline in the NFL odds. The Colts are longshots in Super Bowl odds at +50000.

The Colts and Raiders have alternated wins in the last six meetings. Las Vegas won the most recent game 23-20 last season.

Sam Ehlinger will make his third start since replacing Matt Ryan. The Colts have the worst scoring offense in the NFL, averaging just 14.7 points a game. Ehlinger has completed 32 of 52 passes in two games for 304 yards and no interceptions.

Josh Jacobs is the fourth in the league with 743 rushing yards. Raiders lost to the Jaguars last week and to New Orleans Saints the week before. Davante Adams was upset with the play calling following last game.

Colts running back Jonathan Taylor is expected to play after missing last week's game. Shaquille Leonard, Jelani Woods and Deon Jackson are ruled out for the game against the Raiders. Darren Waller and Hunter Renfrow are on injured reserve.

Saturday will make his debut as interim coach against a struggling team. Colts owner Jim Irsay hired Saturday.