Chiefs vs. Colts Picks, Predictions NFL Week 3: Indianapolis Looks to Spring Home Upset

The Indianapolis Colts are winless and the Kansas City Chiefs are unbeaten. The last meeting between these teams in 2019 saw the Colts winning 19-13 at Arrowhead Stadium.

The Chiefs are a full touchdown favorite against the Colts. The total has dropped to 49 from an opener of 52. Fifty-three percent of the tickets are in support of an Over, but 70% of cash is on the Under.

Chiefs vs. Colts is a game with a spread of 6.5 points. Over 49. 5 yards is the over/under. Jonathan Taylor is over 15.

Chiefs vs. Colts is a game to watch in NFL Week 3. The Colts are favored by 6.5 points. Over/Under is 49.

The Colts are 0-1 after a 24-0 loss to the Jaguars last week. They are 3-point underdogs against the Chiefs, who are 2- 0. Frank Reich led the Colts to an upset of Patrick Mahomes three years ago as 10.5-points underdog.

The Colts beat Kansas City in 2019. Indianapolis is running the ball on more than 60% of its plays and controlling the game for 37 minutes. The Colts are also dealing with injuries to receivers Michael Pittman Jr. and Alec Pierce, while quarterback Matt Ryan is nursing a sore hand.

The Chiefs and Colts are playing each other in the NFL's Week 3. The Colts have a chance to upset the Chiefs. Taylor is the favorite to score a touchdown. The Chiefs have the better run defense. They limited Arizona Cardinals running back James Conner to 26 rushing yards in Week 1.

Chiefs vs. Colts picks made 9/21/2022 at 12:15 p.m. ET.