LSU vs. Southern: Prediction and odds for Week 2 of college football

LSU and Southern have had different starts to their respective seasons. The Tigers lost to Florida State in the Superdome on Sunday night. Southern defeated Florida Memorial 86-0. It's the first time the two teams will meet in a college football game.

LSU is a heavy favorite against Southern in the FBS/FCS clash taking place at Tiger Stadium on Saturday evening. The Tigers are -47.5 points favorites on the moneyline and -50000 on odds. Southern is +2500 favorites. O/U line is 58 points.

LSU and Southern are playing each other in a college football match-up on Saturday. The Tigers are expected to win comfortably. Southern is expected by many to cover the 47.5-point spread. The Jaguars' offense is too explosive to lose the game. LSU ends the week at 1-1 and hands Southern its first loss of the season.