Tennessee vs. LSU prediction, odds, spread: 2022 Week 6 college football picks, best bets from proven model

Tennessee Volunteers are the 3-point favorites against LSU Tigers. Kickoff is set for noon ET from Tiger Stadium. The Volunteers won their first game against Florida two weeks ago. LSU is undefeated in conference play. SportsLine's advanced computer model simulates every FBS college football game 10,000 times. It has made a huge profit for its players in the past six-plus years.

Tennessee vs. LSU is a college football game on Saturday. The game is being played at Neyland Stadium. Tennessee is 6-0-2 in the past eight games in this rivalry.

Tennessee vs. LSU is a college football game. The road team is 6-0-2 in the past eight meetings in this rivalry. Tennessee is 18-6 ATS in their last 24 games following an ATC.

Tennessee is one of the most experienced teams in the SEC. The team is led by quarterback Hendon Hooker, who is a dark horse Heisman candidate. Tennessee has scored at least 34 points per game this season. The defense has been vulnerable at times, but it has made big plays to seal games in crunch time.

Brian Kelly took over the LSU program in the offseason. His first campaign with the Tigers has seen some adversity, but they appear to be heading in right direction. They beat Auburn 21-0 last Saturday. A win over Tennessee on Saturday would be the crown jewel of Kelly's first season at the helm.

SportsLine's model is leaning Under on the total. It projects the teams to combine for 57 points. One side of the spread hits in well over 50% of simulations.