Miami vs. Southern Miss odds, line: 2022 college football picks, Week 2 predictions from proven model

Miami Hurricanes are looking to improve to 2-0 this season when they face Southern Miss Golden Eagles on Saturday at noon ET. Miami beat Bethune-Cookman 70-13 last week. Southern Mississippi suffered a 29-27 loss in four overtimes against Liberty in Week 1. The Hurricanes' are favored by 25.5 points in the latest Miami vs.Southern Miss odds from Caesars Sportsbook. SportsLine's computer model simulates every FBS college football game 10,000 times and has returned a profit of almost $3,500 for $100 players on its top-rated collegeFootball picks against the spread.

Miami (FL) is playing Southern Miss (MS) in the college football season's second game. The spread is Miami ( FL) -25.5. There is a 56-point over/under for the game, which is covered by SportsLine's computer model.

Miami (FL) is a 25-5 favorite against Southern Miss. The game is expected to be a 56-point game.

Miami (FL) is going to have a huge rest advantage against Southern Miss (Mississippi) because they lost to Liberty last week. Miami has covered the spread in six of its last eight games. Southern Mississippi has only one win in its past eight road games and its offense is a one-man band.

Miami beat Liberty last week. Southern Miss is a quality team that took Liberty to four overtimes last Saturday. Miami's running back, Gore, is from Miami and his dad played there. The Golden Eagles have covered the spread in four of their last five games.

Miami (FL) is playing Southern Miss (Miss) in 2022. The model simulates Miami ( FL) vs. Southern Mississippi 10,000 times and it leans Over on the total. It also says one side of the spread has all the value.