Southern Miss vs. Liberty odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2022
![Southern Miss vs. Liberty odds, line, spread: Proven model reveals college football picks, predictions for Week 1, 2022](/img/li/southern-miss-vs-liberty-odds-line-spread-proven-model-reveals-college-football-picks-predictions-for-week-1-2022-1.jpg)
Liberty Flames are favored by 3.5 points against Southern Miss Golden Eagles at 7 p.m. ET on Saturday. The over-under is set at 49. 5. Southern Mississippi finished last in the Conference USA West Division last year. SportsLine Projection Model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,600 for $100 players on its top-rated college Football picks against the spread.