MLB Best Bets: Predictions, Odds for, Padres vs Pirates, Diamondbacks vs. Cardinals, Nationals vs. Giants (4/29/22)

The Padres and Pirates are playing a three-game series tonight at 6:35 PM EST. The Padres have a clear starting pitcher and offense advantage. Darvish is coming off an excellent start and has great numbers against the Pirates. Thompson has struggled against current Padres hitters. The team with the most offensive firepower will win. I would take the Padres up to -125 through the first five innings. They have scored at least seven runs in their previous three games. Manny Machado has been playing like an MVP this season.

Madison Bumgarner is struggling for the Diamondbacks.