MLB Odds: Cubs-White Sox prediction, odds and pick

The Chicago Cubs and Chicago White Sox will meet in the Windy City Showdown at Guaranteed Rate Field on Saturday. The Cubs are third in NL Central and will send out right-handed hurler Keegan Thompson. Johnny Cueto was recently signed by Chicago and has yet to give up a run in his two starts in south side.

Cubs lost to the Reds on Thursday. They are ranked 13th in the league in runs scored with 192. Ian Happ is the best hitter for the Cubs with an average of .275. Keegan Thompson is expected to start for them against the White Sox. He has a 7.94 ERA in two career appearances against them. He's been better in his starts. The game is on Saturday.

The White Sox are 22-22 in their season. Tim Anderson is the team's leading hitter with a .363 average. The team has only scored 161 runs this season, but they have a good pitching staff. Johnny Cueto is 9-10 with 3.48 ERA in 27 career starts against the Cubs. The game is on Saturday at 7:30 p.m.

The Chicago Cubs are the underdogs against their crosstown rivals the White Sox. The White Sox have struggled at home with a 10-12 record.

The final MLB odds are Chicago Cubs +1.5 (-176) against the White Sox.