NBA picks: Knicks vs. 76ers prediction, odds, over/under, spread, injury report for Friday, Jan. 5

The New York Knicks begin a brief two-game road trip by taking on the Philadelphia 76ers on Friday, January 5. Tip-off from the Wells Fargo Center in Philadelphia is set for 7:30 p.m. ET, and the game will air on ESPN. This is the first of four matchups between these Atlantic Division teams.

The injury report for these teams looks light heading into game day. New York only has point guard Malachi Flynn listed as questionable with an ankle injury. Philadelphia has ruled out shooting guard De’Anthony Melton with a back injury. Robert Covington (knee) and Furkan Korkmaz (illness) are questionable.

The 76ers are six-point favorites at DraftKings Sportsbook. Philadelphia is the -225 moneyline favorite, while New York is the +185 underdog. The point total is set at 231.5.

Knicks vs. 76ers, 7:30 p.m. ET

Pick ATS: 76ers -6

New York has won back-to-back games, but both were at home. The Knicks have dropped three straight on the road. Philadelphia is coming off a home win over the Chicago Bulls and is 3-1 over its last four games. The 76ers are 23-10 against the spread this year, which is the second-best mark in the league. The Knicks are 17-15-2 ATS but 9-10-1 on the road. Philadelphia is the best team in the league covering the spread at home, and unless Joel Embiid randomly sits, they should cover in this game.

Over/Under: Over 231.5

Philadelphia has had 63.6% of its games hit the over this season, which is the third-most in the leagues. New York ranks in the middle of the pack, hitting the over in 52.9% of its games. The 76ers and Knicks had game totals over 231.5 in just two of their last three respective games. Philly is averaging 120.7 points per game, while New York averages 115.3. Even if recently they didn’t have high-scoring games, this game should end with at least 232 combined points scored.