NFL picks, predictions against the spread Week 2: Packers rebound vs. Bears; Bills hold off Titans; Vikings oust Eagles

Week 1 was a good start for Sporting News' NFL picks against the spread. The goal is to get better each week as there's more information available about all 32 teams in 2022.

NFL picks, predictions against the spread for Week 2: Packers rebound vs. Bears, Bills hold off Titans, Vikings oust Eagles. Game of the week: Chargers at Chiefs (-3.5, 54 o/u).

The Chiefs are playing the Chargers on Thursday at 8:20 p.m. ET. Chiefs take the early lead in the AFC West. The Chiefs win 27-24 but fail to cover the spread.

NFL picks, predictions against the spread for Week 2: Packers vs. Bears, Bills vs., Titans vs, Vikings vs..

The Bears are 2-0 and the Packers are last in the NFC North. The Bears will come down to earth after overachieving defensively in Matt Eberflus' debut. Aaron Rodgers will be frustrated more by a tricky all-around defense.

The Rams are coming off a bye week and are playing at home against the Falcons. The Falcons didn't have enough offense or defense to hold up against New Orleans last week. Matthew Stafford, Cooper Kupp and Aaron Donald will be looking to make amends for Buffalo woes. Rams win 38-14 and cover the spread.

Matt Rhule's team lost at home to the Giants. Brian Daboll worked for Sean McDermott, who used to work for the Panthers. Christian McCaffrey vs. Saquon Barkley duel will be decided by whoever is supported by the better QB.

Colts beat Texans in Week 1. Dolphins at Ravens is a toss-up. Vikings beat Eagles. The Colts will win 28-17 and cover the spread.

The Ravens are going to play the Dolphins on Sunday at 1 p.m. ET. Last season, Lamar Jackson played poorly against Miami. This time, the team with Tua Tagovailoa is healthy and has a new-look offense. The game will be physical and the Ravens should win 23-17.

Neither New England nor Pittsburgh's offense impressed in Week 1. The Patriots' pass defense has sudden issues while the Steelers are down T.J. Watt. Bill Belichick beats Mike Tomlin again. Jets at Browns is a game to watch.

The Jets' offensive line will be in trouble against Myles Garrett and a ferocious front getting after Joe Flacco. The Browns will shut down the run and the passing game won't get the job done. Jacoby Brissett can lean on more prolific rushing from Nick Chubb and Kareem Hunt.

Tom Brady is 0-4 against the Saints in NFC South regular-season action. The Saints have issues stopping the run and the Bucs are comfortable power running with New Orleans native Leonard Fournette. Todd Bowles will exploit the offensive line well and pressure former Buc Jameis Winston. Buccaneers win 24-20 and cover the spread. Commanders at Lions is a pick 'em.

The Lions are favored to beat the 49ers. Carson Wentz and Jared Goff are connected by the 2016 NFL draft. The Seahawks are playing the San Francisco 49er at 1 p.m. ET.

The 49ers will play their division rivals the Seahawks on Sunday at 4:05 p.m. ET. The 49er's got washed out in Chicago and will use their home field to show their usual offense and more disciplined defense.

The Raiders beat the Chargers 38-34. The Bengals are playing at home against the Cowboys. The Cardinals lost to the Chiefs. They play the Bengals at 4:25 p.m. on Sunday.

Cincinnati Bengals are 0-1 and the Cowboys are 1-0. The Cowboys lost Dak Prescott and will start Cooper Rush instead. Bengals will win 33-17 and cover the spread. Texans are at Broncos.

The Texans settled for a tie against the Colts in Week 2. The Broncos can settle into their home opener with the unsuccessful Wilson revenge trip behind them. Broncos win 30-16 and cover the spread. Titans at Bills (-10, 49.5 o/u).

Bills take on Titans on Monday at 7:15 p.m. ET. Titans have won two straight games in the series. Bills are looking ahead to a division game in Miami.

Vikings beat Packers 31-27 in a high-scoring game. Eagles beat Detroit. Bills beat Titans. Vikings will play the Eagles on Monday at 8:30 p.m. ET.

The NFL's record straight up is 10-5.

The NFL's record against the spread is 9-7.

The season record straight up is 10-5.

The season record against the spread is 9-7.