Notre Dame vs. California odds, prediction, line: 2022 Week 3 college football picks from model on 50-41 run

Notre Dame is 11-point favorite against California in the 2022 college football game. The game starts at 2:30 p.m. ET. Cal is 2-0 after two straight wins. Notre Dame lost 21-10 to Ohio State in Week 1. SportsLine's computer model simulates every FBS college game 10,000 times. It has made a profit of almost $3,400 for $100 players on its college sports picks against the spread.

Notre Dame vs. California is a college football game on Saturday. The money line is Notre Dame -430, while the spread is 11. Notre Irish are 8-2 ATS in their last 10 games overall.

Cal vs. Notre Dame money line is Fighting Irish -430, Golden Bears +328. Over is 4-1 in Golden Bear's last five games in September. Fighting Indian are 8-2 ATS in their last 10 games overall.

California has a solid aerial attack that has played at a high level in 2022. The team is averaging 273 passing yards per game with senior quarterback Jack Plummer under center. Junior receiver Jeremiah Hunter is leading the team with 11 catches for 157 yards and one score. Freshman receiver J. Michael Sturdivant is second on theteam in catches (10) and receiving yards (104).

Michael Mayer is a physical tight end who is good in the run game and in passing game. Lorenzo Styles is an effective receiver who has eight catches for 123 yards in two games. Notre Dame is favored by 50-41.

SportsLine's model is leaning Over on the total. It projects the teams to combine for 42 points. One side of the spread hits in more than 50% of simulations.