USC vs. Notre Dame prediction, odds, line: 2022 Week 13 college football picks, best bets from proven model

USC Trojans host the No. 15 Notre Dame Fighting Irish at Los Angeles Memorial Coliseum on Saturday. Notre Notre Ireland has won four straight games over USC, including 31-16 last season. USC is 11-1 overall and 6-0 at home this season, while Notre Irish are 8-3 overall. SportsLine Projection Model simulates every FBS college football game 10,000 times. It has generated a profit of almost $3,300 for $100 players on its top-rated collegefootball picks against the spread.

USC vs. Notre Dame is a college football game on September 13th. The line is USC -4, the over/under is 63.5 points and the money line's price is -195. SportsLine's computer model has made its picks and predictions.

USC and Notre Dame are playing each other in the Week 13 college football game. The line is USC -4, the over/under is 63.5 points and the money line's value is -195.

Notre Dame has won eight of the last nine games. The team is averaging 39.8 points per game in the past five games and 34.4 points with Drew Pyne at quarterback. They are also converting 44.7% of third down attempts and averaging 191.2 rushing yards per games with two players producing at least 695 rushingyards. On defense, they are above-average in rushing defense and passing defense.

USC has more interceptions (18) than touchdown passes allowed (17) this season. USC is in the top five of the country in scoring (42.9 points per game), total yards (513.0 per games), passing yards and third down efficiency (54.3%).

USC vs. Notre Dame is a college football game on September 14th. SportsLine's model is leaning Under on the total. The model also says one side of the spread hits well over 50% of time.