Purdue vs. Syracuse odds, prediction, line: 2022 Week 3 college football picks from model on 50-41 run

Syracuse Orange (2-0) host the Purdue Boilermakers (1-1) in an ACC vs. Big Ten battle on Saturday afternoon. Both teams have found success on the offensive end this season. Syracuse smoked UConn 48-14 last week, and Purdue shut out Indiana State 56- 0. SportsLine Projection Model simulates every FBS college football game 10,000 times and has generated a profit of almost $3,400 for $100 players on its top-rated collegeFootball picks against the spread since 2011.

Purdue vs. Syracuse is a college football game on Saturday. The money line is Purdue +105, the over/under is 60 points. Purdue is 4-1 ATS in their last five games overall and 6-0 AET in the last seven home games. SportsLine's computer model has picked Purdue.

Purdue vs. Syracuse is a college football game. The line is Purdue -105, Syracuse -125. Purdue is 4-1 ATS in their last 5 games overall and 6-2 AET in last 7 home games.

Syracuse has a nice group of pass catchers to help quarterback Garrett Shrader. Sean Tucker is first on the team in catches (10), receiving yards (101), Devaughn Cooper is a deep threat who can stretch the field for the offense. Oronde Gadsden II is looking to carve a larger role within the Orange offense and is third on team with 6 catches and 81 receivingyards.

Purdue is favored to beat Syracuse. Aidan O'Connell was named to the 2021 All-Big Ten team last season. Charlie Jones is leading the Big Ten in catches (21), receiving yards (286) and receiving touchdowns (4).

SportsLine's model is leaning Under on the total. It projects the teams to combine for 50 points. One side of the spread hits in well over 50% of simulations.