Ohio State vs Indiana prediction in Big Ten football action

Ohio State Buckeyes are undefeated at 9-0 and the No. 2 in the College Football Playoff rankings. They beat Northwestern 21-7 at Ohio Stadium. Indiana is 3-6 overall and 1-5 in Big Ten play this season. Last week, Indiana lost at home to Penn State 45-15. Ohio State is a 40.5 point favorite against Indiana.

Indiana is in a tailspin and its offensive line is likely to be dominated by Ohio State's defensive line. The weather won't help the Hoosiers.

Ohio State is expected to beat Indiana 49-7. Indiana is last in the East Division. The weather should cooperate. The Buckeyes won at Northwestern last weekend.

Ohio State is looking for their first win in the Big Ten football game against Indiana. The weather is dry and calm. It will be a game of passing. Ohio State's backups will get in by the middle of the third quarter.

Ohio State has the No. 1 scoring offense in the Big Ten and the 14th-ranked defense. The weather is expected to be 42 degrees with 12 mph winds in Columbus. Ohio State's defense should be no issue for Indiana's one-dimensional offense.

Ohio State is expected to beat Indiana 45-7 on Saturday. The Hoosiers have lost six games in a row and are 5-16 in the last two seasons.