Oklahoma State vs. Iowa State: Betting odds, spread, predictions and picks

Oklahoma State football is looking to ends its two-game losing skid when it faces Iowa State inside Boone Pickens Stadium on Saturday. Kickoff is scheduled for 2:30 p.m. CT and will air on ESPNU.

Oklahoma State is 1-3 after a 5-0 start. The Cowboys are an underdog for the fifth-straight game. Iowa State has a well-fortified defense and an offense that is starting to find its grove. Oklahoma State's offense is struggling and the team's defense is giving up more than 31 points per game for first time since 2018. Iowa's team is high after scoring three touchdowns in the fourth quarter against West Virginia last week. Coach Gundy is 10-4 in his career against Iowa and 2-2 in Matt Campbell's.

Oklahoma State is 14-10-0 in 2022. Iowa State won't be that good.

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