Opening College Football Week 12 Odds, Spreads and Early Predictions

USC can wrap up at least a share of the Pac-12 regular season title when it visits crosstown rival UCLA at the Rose Bowl in Pasadena, California. USC opened as a 2.5-point favorite. On Friday night, USC routed Colorado 55-17 at home for its third straight win.

USC can wrap up at least a share of the Pac-12 regular season title when it visits crosstown rival UCLA at the Rose Bowl in Pasadena, California. USC is a 2.5-point favorite. On Friday night, USC routed Colorado 55-17 at home for its third straight win. UCLA was upset by Arizona 34-28 at their home.