Saints vs. 49ers Picks, Predictions Week 12: Expect 49ers to run it up on Saints

The New Orleans Saints (4-7) face the San Francisco 49ers (6-4) at home on Sunday. The 49er's are feeling good after a third straight win and are in the NFC West driver's seat. Saints picked up their fourth win in 10 games over the Los Angeles Rams.

The opening line for the game between the Saints and the 49ers was -8.5. Most books have moved the line to 9 points. There is a 50/50 split on the handle. The best place to back the Over is PointsBet, who offer 43 points, and get the Under at 43.

Saints vs. 49ers is a game to watch. The spread is 8.5. Over/Under is 43. Alvin Kamara is under 50.

Saints are playing the 49ers in a game on Sunday. The spread is 8.5. Over/Under is 43. Alvin Kamara is under 50.

49ers are 2-1 against the spread as the favorite. The 49ers defense is the NFL's seventh-best unit. New Orleans has scored 50 points in their last three games. Andy Dalton is struggling to score points for the Saints.

The under has cashed in three of the past four games the Saints played. The Saints can't score points and they face a top-10 defense. With the Niners focused on the run for most of second half, the game won't go Over the total. San Francisco is 28th in total pace and 29th between plays on average.

Saints are running the ball 41.31% of the time, an NFL 16th, and they have 25 carries per game. Alvin Kamara has eclipsed 50 yards only four times this season. The 49ers have the ninth-best rushing defense.

Saints vs. 49ers picks made 11/25/2022 at 8:59 p.m. ET.