Chargers vs. 49ers Picks, Predictions Week 10: 49ers Favored on Sunday Night Football

The Los Angeles Chargers are 5-3 overall and have won four of their last five games. The San Francisco 49ers are 3-1 but have struggled on the road, losing two of three games there. Christian McCaffrey ran for 94 yards and a touchdown and caught 8 passes for 55 yards.

The 49ers opened as 3.5-point favorites against the Chargers. The line has jumped to 7. 5 at most sportsbooks.

The 49ers are favored on Sunday Night Football against the Chargers.

The 49ers are favored on Sunday Night Football against the Chargers. The 49er's last two covers were by a half-point margin. Deebo Samuel and Elijah Mitchell will play for the 49erns. Keenan Allen and Mike Williams are still injured for Chargers, so they won't be able to score many points.

The Chargers are without their two best receivers, but they have RB Austin Ekeler and WR Josh Palmer. San Francisco's defense is among the league's best, allowing just 18.4 points per game. The 49ers average 22.0 points, and 27.5 since the arrival of Christian McCaffrey. Los Angeles has the NFL's third-worst scoring defense, giving up 25.8 points.

Palmer is going to have a big game with both Williams and Allen. He's been Herbert's go-to weapon in the last two weeks with 22 total targets and 17 receptions. The best odds are at DraftKings, where Over 4.5 receptions is listed as -155.

The 49ers are favored to beat the Chargers on Sunday Night Football.