New Orleans Saints vs San Francisco 49ers Odds, Predictions and Best Bets for Week 12

The San Francisco 49ers are looking to keep their three-game winning streak going when they host the New Orleans Saints at 4:25 p.m. ET Sunday at Levi’s Stadium in Santa Clara. The 49er's last victory came on Monday night in Mexico City. New York's Saints lost 27-20 to the visiting Los Angeles Rams last Sunday and have dropped two games in a row as well as four of their last five.

The 49ers are 9.5-point favorites and -450 picks on the moneyline in the NFL odds. The Saints are 23.09% underdogs. San Francisco has +6500 Super Bowl championship odds and New Orleans is listed at +15000. It is expected to be a sunny day with a high of 66 and northwest wind at 5-7 mph.

The Saints won the last game in San Francisco 27-13 in 2020. The Saints’ only visit to Levi”s Stadium was in 2016, when they won 41-23.

Saints quarterback Andy Dalton is coming off a career-best performance against the Rams. Rookie wide receiver Chris Olave caught five passes for 102 yards and a 53-yard TD. The 49ers top the NFL in total yards allowed, but they are 11th in the league in that category.

Jimmy Garoppolo is playing well for the 49ers. He has four touchdown passes against the Cardinals and has thrown for at least two scores in five of his last six games. Cameron Jordan is the only player in the NFL with at at minimum five sacks in each of the last 11 seasons.

Saints defensive tackle Payton Turner (ankle), linebacker Pete Werner ( ankle), and safety J.T. Gray (hamstring) are ruled out. 49ers were hoping to get Arik Armstead back this week, but he's doubtful. Samson Ebukam will return after a two-game absence.

The 49ers are trying for their first four-game winning streak since starting the 2019 season with eight straight victories. The Saints have won only once on the road all season, beating the Atlanta Falcons in their opener.