San Diego Padres at San Francisco Giants odds, picks and prediction

The San Diego Padres (78-82) face the San Francisco Giants (106-54) in the second game of their final three-game series of the season. First pitch is 4:05 p.m. ET at Oracle Park. Padres' Joe Musgrove (11-9, 3.22 ERA) makes his 31st start and 32nd appearance. He needs one strikeout to reach 200 for the first time in his career.

Padres are 1-3 in his four previous starts against the Giants this season. He needs one strikeout to reach 200 in a season for the first time in career.

Giants are 4-1 in his five starts against the Padres this season. Has already set career-bests in ERA, strikeouts and WHIP.

Padres at Giants odds, lines, picks and prediction.

The Giants have won seven games in a row and can clinch the NL West with one more victory. San Francisco has won three of its last four games against the Padres. The Padres have lost seven straight and have only three wins in their last 20 games. They covered the spread in only two of their past 10 games and are 74-86 ATS overall and 39-40 ATC on the road.