San Diego Padres at San Francisco Giants odds, picks and predictions

The San Diego Padres (35-36) and San Francisco Giants (39-32) meet Monday to kick off a 4-game series. First pitch from Oracle Park is set for 9:45 p.m. ET. Let’s analyze BetMGM Sportsbook’s lines around the Padres vs. Giants odds and make our expert MLB picks and predictions for the best bets.

Season series: Padres lead 2-0

The Padres won 5-4 as -151 home favorites Sunday vs. the Tampa Bay Rays. San Diego scored 3 runs in the 3rd inning and 1 run in both the 4th and 5th innings to take a 5-2 that it never gave up despite giving up 2 runs in the 8th frame. San Diego has won back-to-back games on Saturday and Sunday after suffering back-to-back losses on Thursday and Friday.

San Francisco won 7-3 as a +104 road underdog Sunday vs. the Los Angeles Dodgers. The Giants held a 3-2 lead heading into the top of the 6th before they exploded for 4 runs to seal the game and complete the 3-0 sweep of the Dodgers. San Francisco has won 7 straight games heading into this series to move into 2nd place in the NL West, 3 1/2 games back of the division-leading Arizona Diamondbacks.

Padres at Giants projected starters

RHP Michael Wacha vs. RHP Ryan Walker

Wacha (7-2, 2.89 ERA) makes his 14th start. He has a 1.06 WHIP, 2.5 BB/9 and 8.3 K/9 through 74 2/3 IP.

• Last outing: Win, 6 2/3 IP, 0 ER, 4 H, 1 BB, 5 K in a 5-0 home victory Wednesday vs. Cleveland Guardians
• Career vs. San Francisco: 2-0 with a 1.42 ERA (38 IP, 6 ER), 31 H, 32 K, 1.11 WHIP across 7 starts

Walker (2-0, 1.23 ERA) makes his 1st start and 12th appearance. He has a 1.02 WHIP, 1.2 BB/9 and 9.2 K/9 through 14 2/3 IP.

• Last outing: No-decision, 1 1/3 IP, 0 ER, 2 H, 0 BB, 0 K as a reliever in a 7-5 road win Friday vs. Los Angeles Dodgers
• First career start vs. San Diego

Padres at Giants odds

BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7 a.m. ET.

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Padres at Giants picks and predictions

Prediction

Padres 5, Giants 4

LEAN PADRES (-110).

The Giants are the hotter team but have not yet proven they can beat the Padres this year, losing both previous meetings. San Francisco is 18-17 at home this season whereas the Padres are 16-16 on the road, meaning neither team has a whopping advantage here. However, San Diego is 9-1 in the last 10 meetings with San Francisco, earning it the lean here.

PASS.

I could really see this bet going either way and while I am confident in the Padres winning, I’m not confident in them winning by 2 or more runs. However, the Giants at +1.5 (-175) is not worth the juice as they are far too heavy of a favorite in the run line for this game.

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BET OVER 8.5 (-120).

The Over is 5-0 in San Francisco’s last 5 games and 6-1 in its last 7 games overall. The Over is also 5-1 in the last 6 matchups between these clubs and 8-2 in their last 10 meetings.

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