San Francisco Giants vs. Seattle Mariners odds, picks and best bets

The San Francisco Giants will host the Seattle Mariners at Oracle Park on Wednesday at 9:45 p.m. ET. This is the first game of the two-game series. MLB changed the venue to San Fransisco due to unhealthy air conditions caused by wildfires near Seattle.

Drew Smyly and Ljay Newsome are the projected starting pitchers for the Giants and Mariners. Smyley has a 2.92 ERA, 1.14 WHIP, 13.9 K/9 and 3.6 BB in 12/1 IP over 4 games, including 2 starts. Newsom has 3 ERA with 7. 6 K-9, 0 BB and 0.96 WHip in 8 1/3 IP in 3 games.

Last start: No-decision with 4 IP, 3 H, 2 ER, 7 K and 2 BB in 7-3 win vs. the Texas Rangers on August 1.

Newsome's last start was a 1-1/3-inning no-decision. Newsome was forced to leave the game after taking a line drive off his right wrist Sept. 8.

Mitch Haniger, Tom Murphy, Sam Haggerty and J.P. Crawford are out for San Francisco Giants vs. Seattle Mariners.

The game was moved to San Francisco because of the wildfires in Washington. Seattle has won three of four games recently. Giants lost their previous three games on the road. The combined record of Giants-Mariners is 52-35-8 O/U. Giants are favored in over 9 (-110). Seattle is favored over 1.5 (-125). Giants have the fifth-best home run line record in the majors.