Seahawks vs 49ers Odds, Betting Lines, and Picks for Week 2 of NFL Season

Seattle's young offensive line held up well in the Week 1 game. Quarterback Smith was sacked just twice. Seattle has a relatively clean bill of health, except for Jamal Adams being placed on injured reserve. Justin Coleman may not be able to go, so rookie Coby Bryant will play.

Trey Lance started at quarterback for the 49ers last weekend. George Kittle is questionable for this week's game. Elijah Mitchell is out for two months with a sprained MCL. Deebo Samuel rushed for 52 yards and caught two passes for 14 yards in the game against the Bears. The 49er's are favored by nine points.

Pete Carroll has beaten Kyle Shanahan eight times in ten meetings. Seattle won three of the last four games with Russell Wilson at the helm. The 49ers are playing in their own barn and went to the NFC title game a year ago.

Seahawks are +9 (-110) against the 49ers.

Seahawks and 49ers are 1-1 after Week 2 of NFL Season.